looks like updated Windows 10 has a bug in its Windows Defender Smart Screen treatment of ClickOnce type applications, which SimShakers belong to. Instead of warning a user it just blocks an application.
Today, after updating SimShaker for Aviators beta version the application stopped working.
In spite of protecting my PC with Avast, but not Windows Defender, I had to go to Windows Defender Security Center, select App & browser control section and temporarily switch Check app and files option from Warn to Off in order to solve the problem. At the next attempt of starting SimShaker I got the warning window and was able to permit the application to start. I also unchecked "Always ask..." box at warning window to prevent the application from the following checks.
After restoring security Check app and files option back from Off to Warn SimShaker still was able to start.
|Click to enlarge|